WP-1130

CAT: 0013-GTR19171978-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19171978-01Size:5 mg

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Description

Degrasyn (WP1130) is a small molecule inhibitor that targets specific deubiquitinases (DUBs) including USP5 and USP9x, and also inhibits Bcr-Abl and JAK2-STAT signaling. It is utilized in research to study protein degradation pathways and oncogenic signaling in both cellular and animal models of cancer and inflammation.

CAS Number

856243-80-6

Product Name Alternative

Degrasyn

Field of Research

Cell Biology, Protein Biochemistry

Purity

>98%

Bioactivity

DUB inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml) .

Smiles

CCC[C@H] (NC (=O) C (=C\c1cccc (Br) n1) \C#N) c1ccccc1

Molecular Formula

C19H18BrN3O

Molecular Weight

384.28

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

(S, E) -3- (6-bromopyridin-2-yl) -2-cyano-N- (1-phenylbutyl) acrylamide

Chemical Information

Degrasyn

a JAK2 kinase inhibitor that induces rapid degradation of c-Myc protein in MM-1 multiple myeloma and other tumor cell lines; structure in first source

CAS Number	856243-80-6
PubChem CID	11222830
IUPAC Name	(E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide
Molecular Formula	C19H18BrN3O
Molecular Weight	384.3
XLogP	4.3
Topological Polar Surface Area	65.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Heavy Atom Count	24
Formal Charge	0
Complexity	490

SMILES

CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

InChI

InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1

InChIKey

LIDOPKHSVQTSJY-VMEIHUARSA-N

Chemical Structure

2D Structure

CAS: 856243-80-6

CID: 11222830

Formula: C19H18BrN3O

MW: 384.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	384.3
XLogP3	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	383.06332
Monoisotopic Mass	383.06332
Topological Polar Surface Area	65.8 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	490
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19192816-01	RSU 1131
GTR19200415-01	DA 1131
GTR19166446-01	LASSBio-1135
GTR19070224-01	P-113D
GTR19173873-01	SR 11302
GTR19157915-01	LASSBio-1135
GTR19196009	A 113

Alternative Products

Catalog	Name
MBS808041-01	WP-1130
FW166984-01	WP 1130
TBI1351-25MG	WP-1130, DUB inhibitor
452284-01	IN 1130
MBS5769214	IN-1130
TRC-W499550-1G	WP 155
HY-111275	WP-1034
T204230-01	WP 1122

WP-1130

Chemical Information

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