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LASSBio-1135

CAT: 0013-GTR19157915-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157915-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Oral administration of 100 mol x Kg (-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan, however at 10 mol x Kg (-1) only a partial reduction was observed at the 4th h. Neutrophil recruitment and TNF-α production after carrageenan stimulus was also inhibited by the treatment with LASSBio-1135. Modulating TRPV1 and TNF-α production, two key therapeutic targets of neuropathic pain, 100 mol x Kg (-1) LASSBio-1135 was orally efficacious in reversing thermal hyperalgesia and mechanical allodynia produced by partial sciatic ligation 7-11 days after surgery without provoking hyperthermia, a common side effect of TRPV1 antagonists.
CAS Number
852453-71-5
Purity
>98% (HPLC)
Smiles
N (c1c (nc2ccccn12) -c1ccccn1) c1ccccc1
Molecular Formula
C18H14N4
Molecular Weight
286.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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