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ISRIB

CAT: 0013-GTR19171665-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171665-01Size:5 mg
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Description
ISRIB (trans-isomer) is a potent PERK inhibitor (IC50=5 nM) that reverses translational suppression and stress granule assembly induced by phosphorylated eIF2α. This small molecule is a valuable research tool for studying the integrated stress response in cellular and animal models of neurodegeneration and other diseases.
CAS Number
1597403-47-8
Product Name Alternative
Trans-ISRIB
Field of Research
Neuroscience, Protein Biochemistry
Purity
>98%
Bioactivity
Integrated stress response inhibitor
Form
Powder
Solubility
DMSO (up to 5 mg/ml with warming)
Smiles
Clc1ccc (OCC (=O) N[C@H]2CC[C@@H] (CC2) NC (=O) COc2ccc (Cl) cc2) cc1
Molecular Formula
C22H24Cl2N2O4
Molecular Weight
451.34
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N.N’-trans-1,4-Cyclohexanediylbis[2- (4-chlorophenoxy) acetamide

Chemical Information

2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide

ISRIB is an organic molecular entity.

CAS Number1597403-47-8
PubChem CID1011240
IUPAC Name2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
Molecular FormulaC22H24Cl2N2O4
Molecular Weight451.3
XLogP4.8
Topological Polar Surface Area76.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count30
Formal Charge0
Complexity493
SMILES
C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
InChI
InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChIKey
HJGMCDHQPXTGAV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide
CAS: 1597403-47-8
CID: 1011240
Formula: C22H24Cl2N2O4
MW: 451.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight451.3
XLogP34.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass450.1113126
Monoisotopic Mass450.1113126
Topological Polar Surface Area76.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity493
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-12495A-01ISRIB
256959-01Trans-ISRIB

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