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Phloretin

CAT: 0013-GTR19171646-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171646-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phloretin (NSC-407292) is a natural dihydrochalcone and a potent inhibitor of eukaryotic urea transporters, notably blocking VacA-mediated transport. It exhibits strong antioxidative properties and has demonstrated in vitro efficacy in inhibiting proliferation and inducing apoptosis in various cancer cell lines, including B16 melanoma and HL60 leukemia cells.
CAS Number
60-82-2
Product Name Alternative
Dihydronaringenin, NSC407292, NSC-407292, NSC 407292, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, GLUT, Glucose transporter, Sodium-dependent glucose cotransporters, RJC 02792, RJC02792, RJC-02792, Phloretin, SGLT1, SGLT, SGLT2
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
98.53% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.03 mM) ; Ethanol:48 mg/mL (175.01 mM) ; DMSO:80 mg/mL (291.68 mM)
Smiles
C (CCC1=CC=C (O) C=C1) (=O) C2=C (O) C=C (O) C=C2O
Molecular Formula
C15H14O5
Molecular Weight
274.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Phloretin

Phloretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. It has a role as an antineoplastic agent and a plant metabolite. It is functionally related to a dihydrochalcone.

CAS Number60-82-2
PubChem CID4788
IUPAC Name3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Molecular FormulaC15H14O5
Molecular Weight274.27
XLogP2.6
Topological Polar Surface Area98
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity312
SMILES
C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
InChI
InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChIKey
VGEREEWJJVICBM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Phloretin
CAS: 60-82-2
CID: 4788
Formula: C15H14O5
MW: 274.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight274.27
XLogP32.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass274.08412354
Monoisotopic Mass274.08412354
Topological Polar Surface Area98 Ų
Heavy Atom Count20
Formal Charge0
Complexity312
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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