Phloretin

CAT: 0931-T2924-05Size: 5 gDry Ice: NoHazardous: No

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CAT#:0931-T2924-05Size:5 g

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CAS Number

60-82-2

Target

Endogenous Metabolite, SGLT, Urea Transporter, transporter

Related Pathways

Membrane transporter/Ion channel, GPCR/G Protein, Metabolism

Purity

>99.99%

Bioactivity

Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.

Smiles

C(CCC1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2O

Molecular Formula

C15H14O5

Molecular Weight

274.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Phloretin

Phloretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. It has a role as an antineoplastic agent and a plant metabolite. It is functionally related to a dihydrochalcone.

CAS Number	60-82-2
PubChem CID	4788
IUPAC Name	3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Molecular Formula	C15H14O5
Molecular Weight	274.27
XLogP	2.6
Topological Polar Surface Area	98
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	20
Formal Charge	0
Complexity	312

SMILES

C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

InChI

InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2

InChIKey

VGEREEWJJVICBM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 60-82-2

CID: 4788

Formula: C15H14O5

MW: 274.27

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	274.27
XLogP3	2.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	274.08412354
Monoisotopic Mass	274.08412354
Topological Polar Surface Area	98 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	312
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T2S2003-01	Phlorizin dihydrate

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Catalog	Name
FP06961-01	Phloretin
MBS8506141-01	Phloretin (Dihydronaringenin)

Phloretin

Chemical Information

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