YM-58483

• Background:

  YM-58483 is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits antigen-induced histamine release via modulation of mast cell responses.3 Displays potent analgesic actions in various pain models in mice and is orally active.4 Inhibits T cell-mediated immune responses in vivo.5

• Conjugation:

  Unconjugated

• Buffer:

  Off-white solid

• Storage Conditions:

  -20°C