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KY-02327

CAT: 0013-GTR19170607-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170607-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KY-02327 is a metabolically stabilized small molecule that potently inhibits the Dishevelled-CXXC5 protein interaction. This inhibition activates the Wnt/β-catenin signaling pathway, which has been shown in research to stimulate osteoblast differentiation in vitro, making it a useful tool for studying bone formation and regeneration.
CAS Number
2093407-25-9
Product Name Alternative
Wnt, anabolic, anti-osteoporosis, bone, differentiation, Dishevelled, CXXC5-DVL, CXXC5, Inhibitor, osteoblast, inhibit, KY02327, KY-02327, KY 02327
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
93.86% (May vary between batches)
Solubility
DMSO:100 mg/mL (267.77 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.71 mM)
Smiles
C (C (NCCN1CCCCC1) =O) N2C=3C (C=C2C (OCC) =O) =CC (O) =CC3
Molecular Formula
C20H27N3O4
Molecular Weight
373.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ethyl 5-hydroxy-1-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)-1H-indole-2-carboxylate
CAS Number2093407-25-9
PubChem CID142737047
IUPAC Nameethyl 5-hydroxy-1-[2-oxo-2-(2-piperidin-1-ylethylamino)ethyl]indole-2-carboxylate
Molecular FormulaC20H27N3O4
Molecular Weight373.4
XLogP2.5
Topological Polar Surface Area83.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count27
Formal Charge0
Complexity509
SMILES
CCOC(=O)C1=CC2=C(N1CC(=O)NCCN3CCCCC3)C=CC(=C2)O
InChI
InChI=1S/C20H27N3O4/c1-2-27-20(26)18-13-15-12-16(24)6-7-17(15)23(18)14-19(25)21-8-11-22-9-4-3-5-10-22/h6-7,12-13,24H,2-5,8-11,14H2,1H3,(H,21,25)
InChIKey
NJRAXCQBMGIWEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ethyl 5-hydroxy-1-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)-1H-indole-2-carboxylate
CAS: 2093407-25-9
CID: 142737047
Formula: C20H27N3O4
MW: 373.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.4
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass373.20015635
Monoisotopic Mass373.20015635
Topological Polar Surface Area83.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity509
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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