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AX-024

CAT: 0013-GTR19170252-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170252-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AX-024 HCl is a small molecule cytokine release inhibitor that potently suppresses the production of pro-inflammatory cytokines including IL-6, TNF-α, IFN-γ, IL-10, and IL-17A. It is a valuable research tool for studying inflammatory and autoimmune diseases in both in vitro cellular assays and in vivo animal models.
CAS Number
1704801-24-0
Product Name Alternative
Inhibit, Inhibitor, IFNAR, IFN-γ, Interferon-α/β receptor, Interferon-alpha/beta receptor, Interleukin, Interleukin Related, IL-10, IL Receptor, ILReceptor, IL-6, IL-17A, AX 024, AX 024 Hydrochloride, AX 024 hydrochloride, AX024, AX-024, AX-024 HCl, AX024 Hydrochloride, AX024 hydrochloride, AX-024 Hydrochloride, TNF Receptor, TNFR, TNF-α, Tumor Necrosis Factor Receptor
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
Inhibits TCR-dependent T cell activation
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (up to 10 mg/ml with warming)
Smiles
Cl.COc1ccc2OCC (CN3CCCC3) =C (c3ccc (F) cc3) c2c1
Molecular Formula
C21H22FNO2·HCl
Molecular Weight
375.86
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1-[[4- (4-Fluorophenyl) -6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine hydrochloride

Chemical Information

AX-024 hydrochloride
CAS Number1704801-24-0
PubChem CID129909862
IUPAC Name1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine;hydrochloride
Molecular FormulaC21H23ClFNO2
Molecular Weight375.9
Topological Polar Surface Area21.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity480
SMILES
COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4.Cl
InChI
InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H
InChIKey
DGBCIMPGYRVTPD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AX-024 hydrochloride
CAS: 1704801-24-0
CID: 129909862
Formula: C21H23ClFNO2
MW: 375.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass375.1401348
Monoisotopic Mass375.1401348
Topological Polar Surface Area21.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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