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PF-5274857

CAT: 0013-GTR19169708-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169708-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-5274857 is a potent and selective hedgehog pathway inhibitor (Smo IC50: 5.8 nM) with demonstrated blood-brain barrier penetration. Its oral bioavailability and metabolic stability support its use in preclinical research for Hh-driven tumors, including medulloblastoma and brain metastases, as shown in in vivo survival studies.
CAS Number
1373615-35-0
Product Name Alternative
Smoothened, smo, Smo, PF 5274857, PF-5274857, PF-5274857 free base, PF-5274857 freebase, PF5274857, pathway, metastasis, driven, brain
Field of Research
Stem Cell & Developmental Biology
Purity
98.53% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.15 mM) ; DMSO:125 mg/mL (286.07 mM)
Smiles
Cc1cnc (c (C) c1) -c1cc (ncc1Cl) N1CCN (CC1) C (=O) CCS (C) (=O) =O
Molecular Formula
C20H25ClN4O3S
Molecular Weight
436.96
Storage Conditions
-20°C
Notes
For research use only.

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T5465-01PF-5274857
FP143186-01PF 5274857
T35563PF-5274857 hydrochloride
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M23528-01PF-5274857 freebase
FP143187-01PF 5274857 hydrochloride
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A12775-100PF-5274857 100mg
A12775-25PF-5274857 25mg
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