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PF-07284892

CAT: 0013-GTR19218762-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19218762-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-07284892 (ARRY-558) is an orally bioavailable, allosteric inhibitor of SHP2 with an IC50 of 21 nM. It suppresses pERK signaling and has demonstrated antitumor activity in preclinical in vitro and in vivo models, supporting its investigation in oncology research for various solid tumors.
CAS Number
2498597-94-5
Product Name Alternative
ARRY558, ARRY-558, PF07284892
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
97.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.5 mM) ; DMSO:80 mg/mL (181.83 mM)
Smiles
N[C@H]1C2 (CC=3C1=CC=CC3) CCN (CC2) C=4N=CC (SC=5C (Cl) =C (N) N=CC5) =NN4
Molecular Formula
C21H22ClN7S
Molecular Weight
439.96
Storage Conditions
-20°C
Notes
For research use only.

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