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PF-5274857

CAT: 0931-T5465-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T5465-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1373615-35-0
Target
Smo
Related Pathways
Stem Cells
Purity
0.9899
Bioactivity
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM) . PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.
Smiles
Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O
Molecular Formula
C20H25ClN4O3S
Molecular Weight
436.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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S2777-01PF-5274857
FP143186-01PF 5274857
A12775-10PF-5274857 10mg
M23528-01PF-5274857 freebase
FP143187-01PF 5274857 hydrochloride
563691PF-5274857 HCl
A12775-100PF-5274857 100mg
A12775-25PF-5274857 25mg
HY-13459APF-5274857 (hydrochloride)
A12775-50PF-5274857 50mg

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