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Capmatinib 2HCl

CAT: 0013-GTR19168989-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168989-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capmatinib 2HCl (INC-280 2HCl) is a highly potent and selective ATP-competitive c-MET kinase inhibitor (IC50=0.13 nM) . It blocks c-MET phosphorylation and downstream signaling, inhibiting proliferation and migration while inducing apoptosis in c-MET-dependent cancer cells in vitro, and has shown antitumor efficacy in vivo models.
CAS Number
1197376-85-4
Product Name Alternative
SNU-5, S114, U-87MG, H441, HGFR, Inhibitor, orally active, inhibit, INCB28060, INCB-28060, INCB28060 2HCl, INC 280, INCB 28060, INC280, INC-280, INC-280 2HCl, c-Met/HGFR, cMet/HGFR, c-Met, cMet, Balb/c nu/nu mice, Capmatinib, Capmatinib 2HCl, Apoptosis, ATP competitive
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.80% (May vary between batches)
Solubility
DMSO:11 mg/mL (22.66 mM)
Smiles
Cl.Cl.CNC (=O) c1ccc (cc1F) -c1cnc2ncc (Cc3ccc4ncccc4c3) n2n1
Molecular Formula
C23H19Cl2FN6O
Molecular Weight
485.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Capmatinib hydrochloride anhydrous
CAS Number1197376-85-4
PubChem CID44513225
IUPAC Name2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide;dihydrochloride
Molecular FormulaC23H19Cl2FN6O
Molecular Weight485.3
Topological Polar Surface Area85.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity637
SMILES
CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F.Cl.Cl
InChI
InChI=1S/C23H17FN6O.2ClH/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;;/h2-9,11-13H,10H2,1H3,(H,25,31);2*1H
InChIKey
ZTNPHABKLIJXTL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Capmatinib hydrochloride anhydrous
CAS: 1197376-85-4
CID: 44513225
Formula: C23H19Cl2FN6O
MW: 485.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight485.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass484.0981428
Monoisotopic Mass484.0981428
Topological Polar Surface Area85.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity637
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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