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Capmatinib

CAT: 0026-B3005-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:B3005-5Size:5 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capmatinib is an ATP competitive inhibitor of c-MET kinase or hepatocyte growth factor receptor (HGFR). Binding of Hepatocyt Growth Factor to c-MET receptor causes activation of multiple downstream pathways. Capmatinib potently inhibits in vitro kinase activity with an IC₅₀ of 0.13 nM. It prevents HGF-stimulated H441 cell migration with an IC₅₀ value of a ~2 nM. It inhibts c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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