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Capmatinib xHCl

CAT: 0013-GTR19165559-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165559-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capmatinib hydrochloride (INCB28060) is a potent, selective, and orally bioavailable ATP-competitive inhibitor of c-Met kinase. It demonstrates low nanomolar IC50 values in biochemical and cellular assays, effectively blocking both constitutive and HGF-stimulated c-Met activity. This inhibitor is widely used in cancer research, particularly for studying c-Met-dependent tumor models in vitro and in vivo.
CAS Number
1029714-89-3
Product Name Alternative
CMet/HGFR, c-Met/HGFR, c-Met, cMet, Apoptosis, ATP competitive, Capmatinib, Capmatinib hydrochloride (free base), Capmatinib xHCl, Balb/c nu/nu mice, inhibit, INC 280, INC-280, INC280, INCB 28060, INCB28060, INCB-28060, Inhibitor, H441, HGFR, orally active, S114, SNU-5, U-87MG
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.62% (May vary between batches)
Solubility
DMSO:4.49 mg/mL (10 mM)
Smiles
Cl.CNC (=O) c1ccc (cc1F) -c1cnc2ncc (Cc3ccc4ncccc4c3) n2n1
Molecular Formula
C23H18ClFN6O
Molecular Weight
448.89
Storage Conditions
-20°C
Notes
For research use only.

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