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Capmatinib 2HCl

CAT: 0013-GTR19168989-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168989-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capmatinib 2HCl (INC-280 2HCl) is a highly potent and selective ATP-competitive c-MET kinase inhibitor (IC50=0.13 nM) . It blocks c-MET phosphorylation and downstream signaling, inhibiting proliferation and migration while inducing apoptosis in c-MET-dependent cancer cells in vitro, and has shown antitumor efficacy in vivo models.
CAS Number
1197376-85-4
Product Name Alternative
SNU-5, S114, U-87MG, H441, HGFR, Inhibitor, orally active, inhibit, INCB28060, INCB-28060, INCB28060 2HCl, INC 280, INCB 28060, INC280, INC-280, INC-280 2HCl, c-Met/HGFR, cMet/HGFR, c-Met, cMet, Balb/c nu/nu mice, Capmatinib, Capmatinib 2HCl, Apoptosis, ATP competitive
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.80% (May vary between batches)
Solubility
DMSO:11 mg/mL (22.66 mM)
Smiles
Cl.Cl.CNC (=O) c1ccc (cc1F) -c1cnc2ncc (Cc3ccc4ncccc4c3) n2n1
Molecular Formula
C23H19Cl2FN6O
Molecular Weight
485.34
Storage Conditions
-20°C
Notes
For research use only.

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