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PX-478

CAT: 0013-GTR19167917-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167917-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PX-478 is a selective, orally active, and blood-brain barrier permeable HIF-1α inhibitor. It demonstrates antitumor activity in cancer research and has been shown in studies to protect pancreatic β-cell function, making it a compound of interest for type 2 diabetes research.
CAS Number
685898-44-6
Product Name Alternative
Autophagy, HIFProlylHydroxylase, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF-1α, HIF, PX478, PX-478, PX 478
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Metabolism Research
Purity
97.00% (May vary between batches)
Solubility
DMSO:50 mg/mL (126.86 mM) ; H2O:88.81 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.69 mM)
Smiles
Cl.Cl.N[C@@H] (Cc1ccc (cc1) [N+] ([O-]) (CCCl) CCCl) C (O) =O
Molecular Formula
C13H20Cl4N2O3
Molecular Weight
394.12
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Px 478

PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical trial in patients with advanced metastatic cancer and lymphoma. PX-478 was effective in models of both non-small cell lung cancer and small cell lung cancer that express HIF-1 alpha.

CAS Number685898-44-6
PubChem CID11234794
IUPAC Name4-[(2S)-2-amino-2-carboxyethyl]-N,N-bis(2-chloroethyl)benzeneamine oxide;dihydrochloride
Molecular FormulaC13H20Cl4N2O3
Molecular Weight394.1
Topological Polar Surface Area81.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count22
Formal Charge0
Complexity304
SMILES
C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
InChI
InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
InChIKey
GIGCDIVNDFQKRA-LTCKWSDVSA-N
Chemical Structure
2D Structure
2D structure of Px 478
CAS: 685898-44-6
CID: 11234794
Formula: C13H20Cl4N2O3
MW: 394.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass394.019853
Monoisotopic Mass392.022803
Topological Polar Surface Area81.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity304
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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