ARN-21934

CAT: 0804-HY-137466-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137466-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM) . ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research[1].
CAS Number
[2230854-93-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arn-21934.html
Purity
98.08
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
NC1CC2=C(NC3=CC=C(N(C)C)C=C3)N=C(C4=CC=NC=C4)N=C2CC1
Molecular Formula
C21H24N6
Molecular Weight
360.46
Precautions
H302, H315, H319
References & Citations
[1]Jose Antonio Ortega, et al. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020 Nov 12;63 (21) :12873-12886.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II

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