4SC-203

CAT: 0013-GTR19164787-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19164787-03Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

4SC-203 is a potent and selective multi-kinase inhibitor targeting Flt3, Axl, ALK, and related receptors with low nM activity. It has demonstrated anti-proliferative effects in cellular assays and shows promise in preclinical models for oncology research, particularly in leukemia and solid tumors.

CAS Number

895533-09-2

Product Name Alternative

Fms like tyrosine kinase 3, FLT3, FLT3/STK1, Inhibitor, inhibit, multikinase, 4SC 203, 4SC203, 4SC-203, antineoplastic, CD135, Cluster of differentiation antigen 135, tumor, Vascular endothelial growth factor receptor, VEGFR

Field of Research

Cardiovascular Research, Signal Transduction

Purity

96.40% (May vary between batches)

Solubility

DMSO:Slightly soluble

Smiles

COc1ccc (C) cc1NC (=O) Nc1nc2ccc (Nc3ncnc4cc (OCCCN5CCN (C) CC5) c (OC) cc34) cc2s1

Molecular Formula

C33H38N8O4S

Molecular Weight

642.77

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

4Sc-203

4SC-203 has been used in trials studying the treatment of Acute Myeloid Leukemia.

CAS Number	895533-09-2
PubChem CID	44467821
IUPAC Name	1-(2-methoxy-5-methylphenyl)-3-[6-[[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-yl]amino]-1,3-benzothiazol-2-yl]urea
Molecular Formula	C33H38N8O4S
Molecular Weight	642.8
XLogP	5.3
Topological Polar Surface Area	154
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	11
Heavy Atom Count	46
Formal Charge	0
Complexity	963

SMILES

CC1=CC(=C(C=C1)OC)NC(=O)NC2=NC3=C(S2)C=C(C=C3)NC4=NC=NC5=CC(=C(C=C54)OC)OCCCN6CCN(CC6)C

InChI

InChI=1S/C33H38N8O4S/c1-21-6-9-27(43-3)26(16-21)37-32(42)39-33-38-24-8-7-22(17-30(24)46-33)36-31-23-18-28(44-4)29(19-25(23)34-20-35-31)45-15-5-10-41-13-11-40(2)12-14-41/h6-9,16-20H,5,10-15H2,1-4H3,(H,34,35,36)(H2,37,38,39,42)

InChIKey

MAFACRSJGNJHCF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 895533-09-2

CID: 44467821

Formula: C33H38N8O4S

MW: 642.8

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	642.8
XLogP3	5.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	11
Exact Mass	642.27367290
Monoisotopic Mass	642.27367290
Topological Polar Surface Area	154 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	963
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

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GTR19161257-01	4SC-202 tosylate
GTR19160823-01	4SC-202 free base
GTR19162855-01	CPI-203
GTR19029232	MAIT 203
GTR19166444-01	ODM-203
GTR19211616-01	GNE-203
GTR19208149-01	NITD-203
GTR19273773-01	UM-203

Alternative Products

Catalog	Name
T9473-01	4SC-203
TRC-S199210-1G	4SC 203
B4106-10	4SC-202
T68480-01	4SC-207

4SC-203

Chemical Information

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