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ODM-203

CAT: 0013-GTR19166444-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166444-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ODM-203 is a potent, dual inhibitor of FGFR and VEGFR tyrosine kinases, demonstrating robust antitumor efficacy in preclinical models. Its mechanism extends to stimulating antitumor immunity, making it a valuable tool for cancer research in both in vitro and in vivo studies targeting angiogenesis and tumor microenvironment.
CAS Number
1430723-35-5
Product Name Alternative
Inhibit, ODM 203, ODM203, ODM-203, Inhibitor, HUVEC, H1581, FGFR, Fibroblast growth factor receptor, anti-tumor immunity, cancer, RT4, SNU16, Vascular endothelial growth factor receptor, VEGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.77% (May vary between batches)
Solubility
DMSO:13 mg/mL (25.72 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.96 mM)
Smiles
Cn1cc (cn1) -c1ccc2n (cnc2c1) -c1cc (NS (=O) (=O) C2CC2) cc (c1) -c1ccc (F) cc1F
Molecular Formula
C26H21F2N5O2S
Molecular Weight
505.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Odm-203

VEGFR/FGFR Inhibitor ODM-203 is an orally available inhibitor of the human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs), with potential antiangiogenic and antineoplastic activities. VEGFR/FGFR inhibitor ODM-203 inhibits both VEGFRs and FGFRs, which may result in the inhibition of VEGFR- and FGFR-mediated signaling. This leads to an inhibition of angiogenesis and cell proliferation in tumor cells overexpressing VEGFR and/or FGFR. Both VEGFRs and FGFRs belong to the superfamily of receptor tyrosine kinases and are upregulated in various tumor cell types.

CAS Number1430723-35-5
PubChem CID71554322
IUPAC NameN-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
Molecular FormulaC26H21F2N5O2S
Molecular Weight505.5
XLogP4.4
Topological Polar Surface Area90.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity886
SMILES
CN1C=C(C=N1)C2=CC3=C(C=C2)N(C=N3)C4=CC(=CC(=C4)NS(=O)(=O)C5CC5)C6=C(C=C(C=C6)F)F
InChI
InChI=1S/C26H21F2N5O2S/c1-32-14-18(13-30-32)16-2-7-26-25(10-16)29-15-33(26)21-9-17(23-6-3-19(27)11-24(23)28)8-20(12-21)31-36(34,35)22-4-5-22/h2-3,6-15,22,31H,4-5H2,1H3
InChIKey
ZJFCBQXPTQSTCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Odm-203
CAS: 1430723-35-5
CID: 71554322
Formula: C26H21F2N5O2S
MW: 505.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight505.5
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass505.13840243
Monoisotopic Mass505.13840243
Topological Polar Surface Area90.2 Ų
Heavy Atom Count36
Formal Charge0
Complexity886
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-119367-01ODM-203
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