Dalpiciclib

CAT: 0013-GTR19164671-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19164671-01Size:1 mg

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Description

Dalpiciclib (SHR-6390) is a potent and selective oral inhibitor of CDK4/6, exhibiting antitumor activity in models such as esophageal squamous cell carcinoma. It functions by inhibiting Rb phosphorylation, inducing G1 arrest, and has demonstrated efficacy in both in vitro and in vivo studies across various cancer research fields.

CAS Number

1637781-04-4

Product Name Alternative

CDK, CDK4, CDK6, Cyclin dependent kinase, Dalpiciclib, Eca 109, Eca 9706, and KYSE-510 ESCC, antitumor activity, BT-474/T, inhibit, MCF7, MCF7/TR, Inhibitor, SHR6390, SHR-6390, SHR 6390

Field of Research

Cell Biology

Purity

98.32% (May vary between batches)

Solubility

DMSO:< 1 mg/mL (insoluble)

Smiles

O=C1N (C=2C (C (C) =C1C (C) =O) =CN=C (NC3=CC=C (C=N3) C4CCNCC4) N2) C5CCCC5

Molecular Formula

C25H30N6O2

Molecular Weight

446.54

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Dalpiciclib

Dalpiciclib is a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.

CAS Number	1637781-04-4
PubChem CID	86279927
IUPAC Name	6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperidin-4-yl-2-pyridinyl)amino]pyrido[2,3-d]pyrimidin-7-one
Molecular Formula	C25H30N6O2
Molecular Weight	446.5
XLogP	2.5
Topological Polar Surface Area	100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	33
Formal Charge	0
Complexity	773

SMILES

CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)C4CCNCC4)C5CCCC5)C(=O)C

InChI

InChI=1S/C25H30N6O2/c1-15-20-14-28-25(29-21-8-7-18(13-27-21)17-9-11-26-12-10-17)30-23(20)31(19-5-3-4-6-19)24(33)22(15)16(2)32/h7-8,13-14,17,19,26H,3-6,9-12H2,1-2H3,(H,27,28,29,30)

InChIKey

SGJLSPUSUBJWHO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1637781-04-4

CID: 86279927

Formula: C25H30N6O2

MW: 446.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	446.5
XLogP3	2.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	446.24302422
Monoisotopic Mass	446.24302422
Topological Polar Surface Area	100 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	773
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T9636-01	Dalpiciclib
HY-114338B	Dalpiciclib (isethionate)
T63199-01	Dalpiciclib hydrochloride
HY-114338A-01	Dalpiciclib (hydrochloride)
535189	Dalpiciclib free base

Dalpiciclib

Chemical Information

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