Dalpiciclib

CAT: 0957-E0951-25mgSize: 25 mgDry Ice: NoHazardous: No

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CAT#:0957-E0951-25mgSize:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1637781-04-4

Synonyms

SHR-6390

Target

CDK

Applications

Cell Cycle

Molecular Formula

C25H30N6O2

Additionnal Information

Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!

Storage Conditions

3 years -20°C powder

Chemical Information

Dalpiciclib

Dalpiciclib is a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.

CAS Number	1637781-04-4
PubChem CID	86279927
IUPAC Name	6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperidin-4-yl-2-pyridinyl)amino]pyrido[2,3-d]pyrimidin-7-one
Molecular Formula	C25H30N6O2
Molecular Weight	446.5
XLogP	2.5
Topological Polar Surface Area	100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	33
Formal Charge	0
Complexity	773

SMILES

CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)C4CCNCC4)C5CCCC5)C(=O)C

InChI

InChI=1S/C25H30N6O2/c1-15-20-14-28-25(29-21-8-7-18(13-27-21)17-9-11-26-12-10-17)30-23(20)31(19-5-3-4-6-19)24(33)22(15)16(2)32/h7-8,13-14,17,19,26H,3-6,9-12H2,1-2H3,(H,27,28,29,30)

InChIKey

SGJLSPUSUBJWHO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1637781-04-4

CID: 86279927

Formula: C25H30N6O2

MW: 446.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	446.5
XLogP3	2.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	446.24302422
Monoisotopic Mass	446.24302422
Topological Polar Surface Area	100 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	773
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T9636-01	Dalpiciclib
HY-114338B	Dalpiciclib (isethionate)
T63199-01	Dalpiciclib hydrochloride
HY-114338A-01	Dalpiciclib (hydrochloride)
GTR19273263-01	Dalpiciclib isethionate
535189	Dalpiciclib free base

Dalpiciclib

Chemical Information

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