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Dasabuvir

CAT: 0013-GTR19163618-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163618-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABT-333 is an NS5B non-nucleoside polymerase inhibitor. (In Vitro) :Dasabuvir (ABT-333) is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.Dasabuvir (ABT-333) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM.Dasabuvir (ABT-333) inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively.
CAS Number
1132935-63-7
Product Name Alternative
ABT-333
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
CS (=O) (NC1=CC=C2C=C (C3=CC (N (C (N4) =O) C=CC4=O) =CC (C (C) (C) C) =C3OC) C=CC2=C1) =O
Molecular Formula
C26H27N3O5S
Molecular Weight
493.578
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (6- (3- (tert-butyl) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -yl) -2-methoxyphenyl) naphthalen-2-yl) methanesulfonamide

Alternative Products

CatalogName
445809-01Dasabuvir
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HY-13998ADasabuvir (sodium)
HY-13998R-01Dasabuvir (Standard)
AR-D01272-01Dasabuvir-d9
MBS579619Dasabuvir (ABT-333)
AR-D06524-01N-Nitroso Dasabuvir
445810-01Dasabuvir Naphthyl-d6
AR-D01273-01Dasabuvir-13C-d3
TRC-D193553-100MGDasabuvir O-Trideuteromethyl-d3

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