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J147

CAT: 0013-GTR19163584-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163584-01Size:1 g
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Description
J-147 is a broad spectrum neuroprotective phenyl hydrazide compound (EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF) . (In Vitro) :J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM) . (In Vivo) :J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.The half life (t1/2) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain (per oral (PO) administration at a single dose of 20 mg/kg) .
CAS Number
1146963-51-0
Product Name Alternative
J147 | J 147 | J-147
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
O=C (N (C1=CC=C (C) C=C1C) /N=C/C2=CC=CC (OC) =C2) C (F) (F) F
Molecular Formula
C18H17F3N2O2
Molecular Weight
350.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,2,2-Trifluoroacetic acid 1- (2,4-Dimethylphenyl) -2-[ (3-methoxyphenyl) methylene]hydrazide

Chemical Information

J147

J147 is an anilide.

CAS Number1146963-51-0
PubChem CID25229652
IUPAC NameN-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide
Molecular FormulaC18H17F3N2O2
Molecular Weight350.3
XLogP4.7
Topological Polar Surface Area41.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity481
SMILES
CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)/N=C/C2=CC(=CC=C2)OC)C
InChI
InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
InChIKey
HYMZAYGFKNNHDN-SSDVNMTOSA-N
Chemical Structure
2D Structure
2D structure of J147
CAS: 1146963-51-0
CID: 25229652
Formula: C18H17F3N2O2
MW: 350.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.3
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass350.12421228
Monoisotopic Mass350.12421228
Topological Polar Surface Area41.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity481
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19167121-01J14

Alternative Products

CatalogName
522384J147
A15953-50J147 50mg
A15953-100J147 100mg
A15953-500J147 500mg
A15953-5J147 5mg
A15953-25J147 25mg
A15953-10J147 10mg
HY-13779-01(E/Z) -J147
A15953-10mM-DJ147 10mM * 1mL in DMSO
bs-60012C-01J147 --- Neuroprotective Small Molecule

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