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RIPK2-IN-1

CAT: 0013-GTR19163255-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163255-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor. (In Vitro) :GSK2983559 active metabolite is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide.
CAS Number
1423186-80-4
Product Name Alternative
GSK2983559 | GSK-2983559 | GSK 2983559 | RIPK2-IN-1 | RIPK2 IN 1
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=S (C1=CC2=C (NC3=CC=C (SC=N4) C4=C3) N=CN=C2C=C1OCCO) (C (C) (C) C) =O
Molecular Formula
C21H22N4O4S2
Molecular Weight
458.5538
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethanol, 2-[[4- (5-benzothiazolylamino) -6-[ (1,1-dimethylethyl) sulfonyl]-7-quinazolinyl]oxy]-

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