Products for Research Use Only
RegisterLogin

PF-06840003

CAT: 0013-GTR19162885-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19162885-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A novel potent, selective, orally active, and CNS penetrant IDO-1 inhibitor with IC50 of 0.41 uM for hIDO-1; weakly inhibits hTDO-2 with IC50 of 140 uM, and shows no activity against hIDO-2 (>100 uM) ; shows activity both in the HeLa assay (IC50=1.8 uM) as well as in the LPS/INFγ-stimulated THP1 cells (IC50=1.7 uM), maintains good efficiency in the whole blood assay (IC50=4.7 uM) ; shown significant antitumor activity in mice and very favorable ADME profile.Brain Cancer Phase 1 Clinical (In Vitro) :PF-06840003 reverses IDO-1-induced T-cell anergy in vitro. PF-06840003 shows activity both in the HeLa assay (IC50=1.8 μM) as well as in the LPS/ INFγ-stimulated THP1 cells (IC50=1.7 μM) . (In Vivo) :PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours.
CAS Number
198474-05-4
Product Name Alternative
PF06840003 | PF 06840003 | EOS 200271
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 28 mg/mL
Smiles
O=C (C (C1=CNC2=C1C=C (F) C=C2) C3) NC3=O
Molecular Formula
C12H9FN2O2
Molecular Weight
232.2104632
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,5-Pyrrolidinedione, 3- (5-fluoro-1H-indol-3-yl) -

Related Products

CatalogName
GTR19219774-01PF-06821497
GTR19218762-01PF-07284892
GTR19217007-01PF-04745637
GTR19216918-01PF-04885614
GTR19213808-01PF-03463275
GTR19212469-01PF-07054894
GTR19212080-01PF-184
GTR19210491-01PF-07258669
GTR19208369-01PF-04671536
GTR19208220-01PF-05150122

Alternative Products

CatalogName
BA7829-5PF-06840003
BP168137-01PF 06840003
462324-01PF-06840003 discontinued
A20807-25PF-06840003 25mg
A20807-50PF-06840003 50mg
A20807-2PF-06840003 2mg
HY-101111RPF-06840003 (Standard)

Popular Products