Products for Research Use Only
RegisterLogin

YM-58483

CAT: 0013-GTR19163024-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19163024-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM; inhibits Ca (2+) influx through SOC channels without affecting the TCR signal transduction cascade in Jurkat cells, inhibits thapsigargin-induced sustained Ca (2+) influx (IC50=100 nM), and 30-fold less potent against Cav channels; potently inhibits IL-2 production and NF-AT-driven promoter activity in Jurkat cells; also inhibits IL-4 and IL-5 production Th2 T cells, prevents antigen-induced inflammatory responses in animal models; orally active.
CAS Number
223499-30-7
Product Name Alternative
YM58483 | YM 58483 | BPT2
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (C1=C (C) N=NS1) NC2=CC=C (N3N=C (C (F) (F) F) C=C3C (F) (F) F) C=C2
Molecular Formula
C15H9F6N5OS
Molecular Weight
421.3203
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-4-methyl-

Chemical Information

4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide

potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes

CAS Number223499-30-7
PubChem CID2455
IUPAC NameN-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
Molecular FormulaC15H9F6N5OS
Molecular Weight421.3
XLogP3.8
Topological Polar Surface Area101
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity568
SMILES
CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
InChIKey
XPRZIORDEVHURQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide
CAS: 223499-30-7
CID: 2455
Formula: C15H9F6N5OS
MW: 421.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight421.3
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count3
Exact Mass421.04320007
Monoisotopic Mass421.04320007
Topological Polar Surface Area101 Ų
Heavy Atom Count28
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19219162-01YM-08
GTR19213055-01YM-58790
GTR19211985-01YM-1
GTR19196120-01YM-900
GTR19192263YM 11124
GTR19192256YM 212
GTR19192250YM-440
GTR19233888-01YM-344031
GTR19172326-01YM-155
GTR19171422-01YM-90709

Alternative Products

CatalogName
B7542-100YM 58483
bs-82613C-01YM-58483
A16346-2YM-58483 2mg
C13381-1gYM-58483 (BTP2)
A16346-100YM-58483 100mg
A16346-25YM-58483 25mg
A16346-5YM-58483 5mg
A16346-1YM-58483 1mg
HY-100831R-01YM-58483 (Standard)

Popular Products