LY2109761

CAT: 0013-GTR19161711-02Size: 1 gDry Ice: NoHazardous: No

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CAT#:0013-GTR19161711-02Size:1 g

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Description

A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively; completely inhibits TGF-β-induced Sma2 phosphorylation on tumor cells or the liver microenviroment, inhibits the L3.6pl/GLT soft agar growth, suppresses both basal and TGF-β1-induced cell migration and invasion, and stimulates anoikis in vitro; significantly reduces the tumor burden as well as spontaneous abdominal metastases, and prolongs survival combined with gemicitabine in vivo model of pancreatic cancer.

CAS Number

700874-71-1

Product Name Alternative

LY 2109761 | LY-2109761

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

N1 (CCOC2=CC=C3C (C4=C (CCC5) N5N=C4C6=NC=CC=C6) =CC=NC3=C2) CCOCC1

Molecular Formula

C26H27N5O2

Molecular Weight

441.5249

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Quinoline, 4-[5,6-dihydro-2- (2-pyridinyl) -4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2- (4-morpholinyl) ethoxy]-

Chemical Information

LY2109761

a transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

CAS Number	700874-71-1
PubChem CID	11655119
IUPAC Name	4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine
Molecular Formula	C26H27N5O2
Molecular Weight	441.5
XLogP	2.8
Topological Polar Surface Area	65.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	33
Formal Charge	0
Complexity	632

SMILES

C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6

InChI

InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2

InChIKey

IHLVSLOZUHKNMQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 700874-71-1

CID: 11655119

Formula: C26H27N5O2

MW: 441.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	441.5
XLogP3	2.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	441.21647512
Monoisotopic Mass	441.21647512
Topological Polar Surface Area	65.3 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	632
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS3605686-01	LY2109761

LY2109761

Chemical Information

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