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LY2109761

CAT: 0013-GTR19161711-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161711-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively; completely inhibits TGF-β-induced Sma2 phosphorylation on tumor cells or the liver microenviroment, inhibits the L3.6pl/GLT soft agar growth, suppresses both basal and TGF-β1-induced cell migration and invasion, and stimulates anoikis in vitro; significantly reduces the tumor burden as well as spontaneous abdominal metastases, and prolongs survival combined with gemicitabine in vivo model of pancreatic cancer.
CAS Number
700874-71-1
Product Name Alternative
LY 2109761 | LY-2109761
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
N1 (CCOC2=CC=C3C (C4=C (CCC5) N5N=C4C6=NC=CC=C6) =CC=NC3=C2) CCOCC1
Molecular Formula
C26H27N5O2
Molecular Weight
441.5249
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 4-[5,6-dihydro-2- (2-pyridinyl) -4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2- (4-morpholinyl) ethoxy]-

Chemical Information

LY2109761

a transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

CAS Number700874-71-1
PubChem CID11655119
IUPAC Name4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine
Molecular FormulaC26H27N5O2
Molecular Weight441.5
XLogP2.8
Topological Polar Surface Area65.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity632
SMILES
C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6
InChI
InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
InChIKey
IHLVSLOZUHKNMQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of LY2109761
CAS: 700874-71-1
CID: 11655119
Formula: C26H27N5O2
MW: 441.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.5
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass441.21647512
Monoisotopic Mass441.21647512
Topological Polar Surface Area65.3 Ų
Heavy Atom Count33
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3605686-01LY2109761

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