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R-IMPP

CAT: 0804-HY-101354-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101354-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1].
CAS Number
2133832-83-2
Product Name Alternative
PF-00932239
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/R-IMPP.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C1=NC=CC2=C1C=CC=C2)[C@H]3CNCCC3)CCC4=CC=C(OC)C=C4
Molecular Formula
C24H27N3O2
Molecular Weight
389.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23 (11) :1362-1371
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

R-Impp
CAS Number2133832-83-2
PubChem CID122198706
IUPAC NameN-isoquinolin-1-yl-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide
Molecular FormulaC24H27N3O2
Molecular Weight389.5
XLogP3.8
Topological Polar Surface Area54.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity520
SMILES
COC1=CC=C(C=C1)CCC(=O)N([C@@H]2CCCNC2)C3=NC=CC4=CC=CC=C43
InChI
InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1
InChIKey
OKTGXQMSOIQCTJ-HXUWFJFHSA-N
Chemical Structure
2D Structure
2D structure of R-Impp
CAS: 2133832-83-2
CID: 122198706
Formula: C24H27N3O2
MW: 389.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.5
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass389.21032711
Monoisotopic Mass389.21032711
Topological Polar Surface Area54.5 Ų
Heavy Atom Count29
Formal Charge0
Complexity520
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T4058-01R-IMPP
A20678-10R-IMPP 10mg
A20678-5R-IMPP 5mg
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A20678-100R-IMPP 100mg
A20678-1R-IMPP 1mg
A20678-25R-IMPP 25mg
A20678-50R-IMPP 50mg
A20678-2R-IMPP 2mg
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