R-IMPP

R-IMPP

• CAS Number: 2133832-83-2
• UNSPSC Description: R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1].
• Target Antigen: PCSK9
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/R-IMPP.html
• Purity: 98.42
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N(C1=NC=CC2=C1C=CC=C2)[C@H]3CNCCC3)CCC4=CC=C(OC)C=C4
• Molecular Weight: 389.49
• References & Citations: [1]Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported