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Acyclovir

CAT: 0013-GTR19161336-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19161336-01Size:1 g
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Description
An antiviral agent that competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes; primarily used for the treatment of HSV infections.HSV Infection Approved (In Vitro) :Acyclovir (Aciclovir, 3-100 μM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent.Acyclovir (Aciclovir, 10-100 μM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner.Acyclovir (Aciclovir, 10-100 μM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation. (In Vivo) :Acyclovir (20 mg/kg; p.o.; three times daily; for 10 days; BALB/c mice) treatment in infected mice suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production.
CAS Number
59277-89-3
Product Name Alternative
Aciclovir | Acycloguanosine
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
NC1=NC (=O) C2=C (N1) N (COCCO) C=N2
Molecular Formula
C8H11N5O3
Molecular Weight
225.2046
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[ (2-hydroxyethoxy) methyl]-

Chemical Information

Acyclovir

Acyclovir is an oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. It has a role as an antimetabolite and an antiviral drug. It is a member of 2-aminopurines and an oxopurine. It is functionally related to a guanine.

CAS Number59277-89-3
PubChem CID135398513
IUPAC Name2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one
Molecular FormulaC8H11N5O3
Molecular Weight225.20
XLogP-1.9
Topological Polar Surface Area115
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count16
Formal Charge0
Complexity308
SMILES
C1=NC2=C(N1COCCO)N=C(NC2=O)N
InChI
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChIKey
MKUXAQIIEYXACX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Acyclovir
CAS: 59277-89-3
CID: 135398513
Formula: C8H11N5O3
MW: 225.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight225.20
XLogP3-1.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass225.08618923
Monoisotopic Mass225.08618923
Topological Polar Surface Area115 Ų
Heavy Atom Count16
Formal Charge0
Complexity308
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GA7641-1gAcyclovir
CS-O-02866Acyclovir-d4
FA07187-01Acyclovir monophosphate
HY-17422CAcyclovir alaninate
HY-17422DAcyclovir (hydrochloride)
HY-17422R-01Acyclovir (Standard)

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