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ISO-1

CAT: 0013-GTR19160318-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160318-02Size:2 mg
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Description
ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.
CAS Number
478336-92-4
Product Name Alternative
ISO-1 | ISO 1 | ISO1 | MIF Antagonist
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 36 mg/mL; 153.04 mM
Smiles
COC (=O) CC1CC (=NO1) c1ccc (O) cc1
Molecular Formula
C12H13NO4
Molecular Weight
235.2
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4,5-dihydro-3- (4-hydroxyphenyl) -5-isoxazoleacetic acid, methyl ester

Chemical Information

3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester

5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester is a member of phenols.

CAS Number478336-92-4
PubChem CID4633677
IUPAC Namemethyl 2-[3-(4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetate
Molecular FormulaC12H13NO4
Molecular Weight235.24
XLogP1.3
Topological Polar Surface Area68.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity308
SMILES
COC(=O)CC1CC(=NO1)C2=CC=C(C=C2)O
InChI
InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
InChIKey
AIXMJTYHQHQJLU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester
CAS: 478336-92-4
CID: 4633677
Formula: C12H13NO4
MW: 235.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight235.24
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass235.08445790
Monoisotopic Mass235.08445790
Topological Polar Surface Area68.1 Ų
Heavy Atom Count17
Formal Charge0
Complexity308
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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