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AST 487

CAT: 0013-GTR19160285-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160285-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AST487, also known as NVP- AST487, is a RET kinase inhibitor/FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP- AST487 has an IC (50) of 0.88 mumol/L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. NVP- AST487 induced a dose-dependent growth inhibition of xenografts of NIH3T3 cells expressing oncogenic RET, and of the MTC cell line TT in nude mice. NVP- AST487 inhibited calcitonin gene expression in vitro in TT cells, in part, through decreased gene transcription.
CAS Number
630124-46-8
Product Name Alternative
NVPAST487 | AST 487
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 188.84 mM
Smiles
CNc1cc (Oc2ccc (NC (=O) Nc3ccc (CN4CCN (CC) CC4) c (C (F) (F) F) c3) cc2) ncn1
Molecular Formula
C26H30F3N7O2
Molecular Weight
529.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4- ((4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) -3- (4- ((6- (methylamino) pyrimidin-4-yl) oxy) phenyl) urea

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