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BMS-3

CAT: 0013-GTR19159688-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159688-01Size:200 mg
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Description
BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
CAS Number
1338247-30-5
Product Name Alternative
BMS-3 | BMS 3 | BMS3
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL6; 9.89 mM
Smiles
O=C (Nc1ncc (s1) c2cc (nn2c3c (Cl) cccc3Cl) C (F) F) C4CC4
Molecular Formula
C17H12Cl2F2N4OS
Molecular Weight
429.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[5-[2- (2,6-Dichlorophenyl) -5- (difluoromethyl) pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide

Chemical Information

Bms-3
CAS Number1338247-30-5
PubChem CID73265272
IUPAC NameN-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)pyrazol-5-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide
Molecular FormulaC17H12Cl2F2N4OS
Molecular Weight429.3
XLogP4.5
Topological Polar Surface Area88.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity549
SMILES
C1CC1C(=O)NC2=NC=C(S2)C3=CC(=NN3C4=C(C=CC=C4Cl)Cl)C(F)F
InChI
InChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
InChIKey
YBGGBHCJSAEIAS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bms-3
CAS: 1338247-30-5
CID: 73265272
Formula: C17H12Cl2F2N4OS
MW: 429.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.3
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass428.0076939
Monoisotopic Mass428.0076939
Topological Polar Surface Area88.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity549
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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