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SKI II

CAT: 0013-GTR19160113-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160113-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM) . nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells.
CAS Number
312636-16-1
Product Name Alternative
SKI-II | SKI II. Sphingosine kinase inhibitor II
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 330.27 mM
Smiles
C1cc (ccc1c1csc (n1) Nc1ccc (cc1) O) Cl
Molecular Formula
C15H11ClN2OS
Molecular Weight
302.78
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[[4- (4-Chlorophenyl) -2-thiazolyl]amino]phenol

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