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SKI-178

CAT: 0013-GTR19166930-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166930-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKI-178 is a potent SphK1 inhibitor (IC50 0.1-1.8 μM) that triggers prolonged mitosis and intrinsic apoptosis. This effect is mediated by sustained CDK1 activity, which phosphorylates Bcl-2 and Bcl-xL while degrading Mcl-1. It serves as a valuable chemical probe for studying sphingolipid signaling, cell cycle arrest, and apoptosis in cancer research models.
CAS Number
1259484-97-3
Product Name Alternative
Myeloid, multi-drug, inhibit, Inhibitor, leukemia, cell, drug, cytotoxic, cancer, Apoptosis, sensitive, S1P Receptor, S1PReceptor, resistant, SphK1, SphK2, SphK, Sphingosine kinase, SKI 178, SKI178, SKI-178
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
97.09% (May vary between batches)
Solubility
DMSO:50 mg/mL (126.77 mM) ;10% DMSO+90% Corn Oil:2.5 mg/mL (6.34 mM)
Smiles
COc1ccc (cc1) -c1cc ([nH]n1) C (=O) N\N=C (/C) c1ccc (OC) c (OC) c1
Molecular Formula
C21H22N4O4
Molecular Weight
394.42
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

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BA2877-5.1SKI-178
JAC48497-01SKI 178
A22510-50SKI-178 50mg
A22510-5SKI-178 5mg
A22510-2SKI-178 2mg
A22510-500SKI-178 500mg
A22510-100SKI-178 100mg
A22510-25SKI-178 25mg
A22510-10SKI-178 10mg
A22510-10mM-DSKI-178 10mM * 1mL in DMSO

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