SKI-178

CAT: 0013-GTR19156310-01Size: 1 gDry Ice: NoHazardous: No

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CAT#:0013-GTR19156310-01Size:1 g

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.

CAS Number

1259484-97-3

Purity

>98% (HPLC)

Solubility

DMSO:50 mg/mL (126.77 mM; Need ultrasonic)

Smiles

O=C (C1=CC (C2=CC=C (OC) C=C2) =NN1) N/N=C (C3=CC=C (OC) C (OC) =C3) \C

Molecular Formula

C21H22N4O4

Molecular Weight

394.43

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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Alternative Products

Catalog	Name
BA2877-5.1	SKI-178
JAC48497-01	SKI 178
A22510-50	SKI-178 50mg
A22510-5	SKI-178 5mg
A22510-2	SKI-178 2mg
A22510-500	SKI-178 500mg
A22510-100	SKI-178 100mg
A22510-25	SKI-178 25mg
A22510-10	SKI-178 10mg
A22510-10mM-D	SKI-178 10mM * 1mL in DMSO

SKI-178

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