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Dehydrocostus Lactone

CAT: 0013-GTR19159216-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159216-01Size:1 g
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Description
Dehydrocostus Lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ. Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways. Dehydrocostus Lactone Inhibits Proliferation, Antiapoptosis, and Invasion of Cervical Cancer Cells Through PI3K/Akt Signaling Pathway.
CAS Number
477-43-0
Product Name Alternative
Dehydrocostus Lactone | (-) -Dehydrocostus lactone.
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 62.5 mg/mL; 271.39 mM
Smiles
C=C1CC[C@@H]2[C@@H] ([C@@H]3[C@H]1CCC3=C) OC (=O) C2=C
Molecular Formula
C15H18O2
Molecular Weight
230.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3aS,6aR,9aR,9bS) -3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2 (3H) -one

Chemical Information

(-)-Dehydrocostus lactone

Dehydrocostus lactone is an organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. It has a role as a metabolite, an antineoplastic agent, a trypanocidal drug, a cyclooxygenase 2 inhibitor, an antimycobacterial drug and an apoptosis inducer. It is an organic heterotricyclic compound, a guaiane sesquiterpenoid, a gamma-lactone and a sesquiterpene lactone.

CAS Number477-43-0
PubChem CID73174
IUPAC Name(3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
Molecular FormulaC15H18O2
Molecular Weight230.30
XLogP2.6
Topological Polar Surface Area26.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count17
Formal Charge0
Complexity432
SMILES
C=C1CC[C@@H]2[C@@H]([C@@H]3[C@H]1CCC3=C)OC(=O)C2=C
InChI
InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChIKey
NETSQGRTUNRXEO-XUXIUFHCSA-N
Chemical Structure
2D Structure
2D structure of (-)-Dehydrocostus lactone
CAS: 477-43-0
CID: 73174
Formula: C15H18O2
MW: 230.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight230.30
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass230.130679813
Monoisotopic Mass230.130679813
Topological Polar Surface Area26.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
HY-N0591-01Dehydrocostus Lactone

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