Dehydrocostus Lactone

• Description:

  Dehydrocostus Lactone ((-) -Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells[1][2][3][4].

• Product Name Alternative:

  (-) -Dehydrocostus lactone; Epiligulyl oxide

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Akt; Apoptosis; Bacterial; Caspase; Interleukin Related; MAPKAPK2 (MK2) ; NF-κB; NO Synthase; p38 MAPK

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Dehydrocostus-Lactone.html

• Purity:

  99.98

• Solubility:

  DMSO : 250 mg/mL (ultrasonic) |Ethanol : 15 mg/mL (ultrasonic)

• Smiles:

  O=C(O[C@@]([C@@]1([H])C(CC[C@@]21[H])=C)([H])[C@@]3([H])CCC2=C)C3=C

• Molecular Formula:

  C15H18O2

• Molecular Weight:

  230.30

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Eun Ji Kim, et al. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food and Chemical Toxicology Volume 46, Issue 12, December 2008, Pages 3651–3658|[2]Nie Y, Wang Z, Chai G, et al. Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt. Molecules. 2019;24 (8) :1510. |[3]Taniguchi M, et al. Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. Biosci Biotechnol Biochem. 1995 Nov;59 (11) :2064-7.|[4]Cantrell CL, et al. Antimycobacterial activities of dehydrocostus lactone and its oxidation products. J Nat Prod. 1998 Oct;61 (10) :1181-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [477-43-0]