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2',5'-Dideoxyadenosine

CAT: 0013-GTR19157738-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157738-02Size:5 mg
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Description
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM) .2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh) . 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of FrEtOAc in rats.
CAS Number
6698-26-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (531.37 mM)
Smiles
C[C@H]1O[C@H] (C[C@@H]1O) n1cnc2c (N) ncnc12
Molecular Formula
C10H13N5O2
Molecular Weight
235.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine is a deoxyribonucleoside.

CAS Number6698-26-6
PubChem CID65166
IUPAC Name(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-methyloxolan-3-ol
Molecular FormulaC10H13N5O2
Molecular Weight235.24
XLogP-0.1
Topological Polar Surface Area99.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity292
SMILES
C[C@@H]1[C@H](C[C@@H](O1)N2C=NC3=C(N=CN=C32)N)O
InChI
InChI=1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
InChIKey
FFHPXOJTVQDVMO-DSYKOEDSSA-N
Chemical Structure
2D Structure
2D structure of 2',5'-Dideoxyadenosine
CAS: 6698-26-6
CID: 65166
Formula: C10H13N5O2
MW: 235.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight235.24
XLogP3-0.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass235.10692467
Monoisotopic Mass235.10692467
Topological Polar Surface Area99.1 Ų
Heavy Atom Count17
Formal Charge0
Complexity292
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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