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2',5'-Dideoxyadenosine

CAT: 0013-GTR19157738-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157738-01Size:1 g
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Description
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM) .2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh) . 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of FrEtOAc in rats.
CAS Number
6698-26-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (531.37 mM)
Smiles
C[C@H]1O[C@H] (C[C@@H]1O) n1cnc2c (N) ncnc12
Molecular Formula
C10H13N5O2
Molecular Weight
235.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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