2',5'-Dideoxyadenosine (Standard)

• Description:

  2',5'-Dideoxyadenosine (Standard) is the analytical standard of 2',5'-Dideoxyadenosine. This product is intended for research and analytical applications. 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

• UNSPSC:

  12352100

• Target:

  Adenylate Cyclase; Adrenergic Receptor; Reference Standards

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research:

  Metabolic Disease

• Smiles:

  C[C@@H]1[C@H] (C[C@H] (N2C=NC3=C (N=CN=C32) N) O1) O

• Molecular Formula:

  C10H13N5O2

• Molecular Weight:

  235.25

• References & Citations:

  [1]Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38 (6) :848-53.|[2]Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25 (3) :331-8.|[3]Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33 (5) :6622-6631.|[4]Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae) . J Ethnopharmacol. 2013 Oct 28;150 (1) :154-61.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  6698-26-6