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RAT ANTI MOUSE CD51

CAT: 0544-MBS214312-01Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS214312-01Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[CD51]
NCBI Gene ID
16410
Reactivity
Mouse
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
Rat anti Mouse CD51 antibody, clone RMV-7 recognizes murine CD51, a ~140 kDa alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61.

Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing.

Rat anti Mouse CD51 antibody, clone RMV-7 has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity (Takahashi et al. 1990).
Other Gene Names
[Itgav; Itgav; CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik]
Short Name
[CD51]
Other Product Names
[integrin alpha-V; Integrin alpha-V; integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha; integrin alpha V; Vitronectin receptor subunit alpha; CD_antigen: CD51Cleaved into the following 2 chains:Integrin alpha-V heavy chain; Integrin alpha-V light chain]
NCBI GI Number
154240716
NCBI Accession Number
NP_032428.2
NCBI GB Accession Number
NM_008402.3
Uniprot Accession Number
P43406

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