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Physalin F

CAT: 0013-GTR19156832-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156832-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infectionPhysalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. A concentration-dependent inhibition of spontaneous proliferation of PBMC from HAM/TSP subjects was observed in the presence of physalin F, as evaluated by (3) H-thymidine uptake. The IC50 for physalin F was 0.97 0.11 μM. Flow cytometry analysis using Cytometric Bead Array (CBA) showed that physalin F (10 μM) significantly reduced the levels of IL-2, IL-6, IL-10, TNF-α and IFN-γ, but not IL-17A, in supernatants of PBMC cultures. Next, apoptosis induction was addressed by using flow cytometry to evaluate annexin V expression. Treatment with physalin F (10 μM) increased the apoptotic population of PBMC in HAM/TSP subjects. Transmission electron microscopy analysis of PBMC showed that physalin F induced ultrastructural changes, such as pyknotic nuclei, damaged mitochondria, enhanced autophagic vacuole formation, and the presence of myelin-like figures. In conclusion, physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by HTLV-1 infection.
CAS Number
57423-71-9
Purity
>98% (HPLC)
Smiles
[H][C@@]12C (=O) [C@]34O[C@]11[C@@] (C) (OC (=O) [C@@]1 (O) CC[C@@]1 ([H]) [C@@]3 ([H]) C[C@H]3O[C@]33CC=CC (=O) [C@]13C) [C@H]1C[C@]2 (C) [C@@] ([H]) (CO4) C (=O) O1
Molecular Formula
C28H30O10?
Molecular Weight
526.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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