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Physalin A

CAT: 0013-GTR19180818-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19180818-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Physalin A, a natural compound from Physalis alkekengi, exhibits anti-inflammatory and anti-fibrotic activity by modulating the Nrf2 pathway via ERK/p38 and inhibiting NF-κB signaling. It also reduces mammosphere formation by downregulating GLI1 and YAP1, making it a useful research tool for studying fibrosis, inflammation, and cancer stem cells in vitro.
CAS Number
23027-91-0
Product Name Alternative
ERK, p53, NF-κB, JNK, JAK, Autophagy, Apoptosis, Androgen Receptor, Bcl-2, p38 MAPK, Physalin A, STAT, ROS
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.71% (May vary between batches)
Solubility
DMSO:55.34 mg/mL (105.1 mM)
Smiles
C[C@@]12[C@]34[C@] ([C@]5 (C) C[C@]1 (OC (=O) C5=C) [H]) (C (=O) [C@] (O) (O3) [C@]6 ([C@] (CC[C@]4 (O) C (=O) O2) ([C@]7 (C) C (=C[C@H]6O) CC=CC7=O) [H]) [H]) [H]
Molecular Formula
C28H30O10
Molecular Weight
526.53
Storage Conditions
Keep away from moisture, keep away from direct sunlight, store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Physalin A

Physalin A is a physalin.

CAS Number23027-91-0
PubChem CID44577487
IUPAC Name(1S,2S,3R,5R,6S,7R,14R,15S,18R,21S,22R)-5,7,18-trihydroxy-1,14,21-trimethyl-25-methylidene-4,20,23-trioxaheptacyclo[20.3.1.12,5.03,18.03,21.06,15.09,14]heptacosa-8,11-diene-13,19,24,27-tetrone
Molecular FormulaC28H30O10
Molecular Weight526.5
XLogP0
Topological Polar Surface Area157
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count0
Heavy Atom Count38
Formal Charge0
Complexity1350
SMILES
C[C@]12C[C@H]([C@]3([C@]45[C@H]1C(=O)[C@](O4)([C@H]6[C@H](CC[C@@]5(C(=O)O3)O)[C@@]7(C(=C[C@H]6O)CC=CC7=O)C)O)C)OC(=O)C2=C
InChI
InChI=1S/C28H30O10/c1-12-21(32)36-17-11-23(12,2)19-20(31)27(35)18-14(24(3)13(10-15(18)29)6-5-7-16(24)30)8-9-26(34)22(33)37-25(17,4)28(19,26)38-27/h5,7,10,14-15,17-19,29,34-35H,1,6,8-9,11H2,2-4H3/t14-,15+,17+,18-,19-,23+,24-,25-,26-,27+,28-/m0/s1
InChIKey
VELDODQHYQSJOF-RPKVKFPNSA-N
Chemical Structure
2D Structure
2D structure of Physalin A
CAS: 23027-91-0
CID: 44577487
Formula: C28H30O10
MW: 526.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight526.5
XLogP30
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count0
Exact Mass526.18389715
Monoisotopic Mass526.18389715
Topological Polar Surface Area157 Ų
Heavy Atom Count38
Formal Charge0
Complexity1350
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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TRC-P397900-1MGPhysalin A
VEA84918-01Physalin O
TN4776Physalin D
583133Physalin F
MBS3612675-01Physalin L
MBS5786776Physalin B
MBS5762941Physalin G
TN7372-01Physalin X

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