Products for Research Use Only
RegisterLogin

BOT-64

CAT: 0013-GTR19156699-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19156699-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compoundBOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB. BOT-64 inhibits LPS-inducible IKKbeta activity in the cells and catalytic activity of highly purified IKKbeta. Moreover, the effect of BOT-64 on cell-free IKKbeta was abolished by substitution of Ser-177 and Ser-181 residues in the activation loop of IKKbeta to glutamic acid residues, indicating a direct interaction site of benzoxathiole. BOT-64 attenuates NF-kappaB-regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL) -1beta, and IL-6 in LPS-activated or expression vector IKKbeta-transfected macrophages.
CAS Number
113760-29-5
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (365.83 mM)
Smiles
CC1 (C) Cc2oc (=Nc3ccccc3) sc2C (=O) C1
Molecular Formula
C15H15NO2S
Molecular Weight
273.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

1,3-Benzoxathiol-4(5H)-one, 6,7-dihydro-6,6-dimethyl-2-(phenylimino)-
CAS Number113760-29-5
PubChem CID13925917
IUPAC Name6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one
Molecular FormulaC15H15NO2S
Molecular Weight273.4
XLogP3.8
Topological Polar Surface Area64
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity459
SMILES
CC1(CC2=C(C(=O)C1)SC(=NC3=CC=CC=C3)O2)C
InChI
InChI=1S/C15H15NO2S/c1-15(2)8-11(17)13-12(9-15)18-14(19-13)16-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3
InChIKey
XFSSJIQCIPSBHJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,3-Benzoxathiol-4(5H)-one, 6,7-dihydro-6,6-dimethyl-2-(phenylimino)-
CAS: 113760-29-5
CID: 13925917
Formula: C15H15NO2S
MW: 273.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight273.4
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass273.08234989
Monoisotopic Mass273.08234989
Topological Polar Surface Area64 Ų
Heavy Atom Count19
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19273004-01HDAC6-IN-64
GTR19240989-01NLRP3-IN-64
GTR19230362-01HDAC-IN-64
GTR19171805-01E-64
GTR19171383-01MN-64
GTR19161058-01E-64
GTR19160176-01MN-64
GTR19335078-01FM4-64
GTR19196976-01NB-64
GTR19187336-01EGFR-IN-64

Alternative Products

CatalogName
HY-136741-01BOT-64
sc-222062NFκB Activation Inhibitor VI, BOT-64
FBPC-117Bot Probe
sc-80649GM-CSFRα (8G6 BOT)
sc-80651IL-3Rα (6H6 BOT)
CHR24905mL CrimpVial Clear Rounded bot
8060007TUBES: CENTRIFUGE, CON BOT PLAIN 15ML
431843250mL PC Centri Bot w ScrewCap - PK36
3180081EVAP DISH: FL BOT WITH POUR OUT 150X80
431847500mL PC Centri Bot w ScrewCap - PK24

Popular Products