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ACBI1

CAT: 0013-GTR19155817-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155817-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
CAS Number
2375564-55-7
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (106.83 mM)
Smiles
CC (N=CS1) =C1C2=CC=C (CNC ([C@@H]3C[C@@H] (O) CN3C ([C@H] (C (C) (C) C) NC (C4 (CC4) F) =O) =O) =O) C (OCCOC5=CC=C (CN6CCN (C7=CC (C8=C (O) C=CC=C8) =NN=C7N) CC6) C=C5) =C2
Molecular Formula
C49H58FN9O7S
Molecular Weight
936.1
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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