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ACBI2

CAT: 0013-GTR19220745-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220745-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACBI2 is a potent, orally bioavailable VHL-based PROTAC that selectively degrades SMARCA2 with high potency (DC50 = 1 nM in RKO cells) . It serves as a valuable chemical probe for investigating SMARCA2 biology and its therapeutic potential in cancers, including lung cancer, in both cellular and animal models.
CAS Number
2913161-19-8
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C1N=C2N (C=3C (N2C4CCCC4) =CC (=CC3) C5CCN (CC[C@H] (CC[C@H] (NC (=O) [C@H]6N (C ([C@@H] (NC (=O) C7 (F) CC7) C (C) (C) C) =O) C[C@H] (O) C6) C8=CC=C (C=C8) C9=C (C) N=CS9) C) CC5) C=%10C1=C (Br) C=CC%10
Molecular Formula
C56H68BrFN8O5S
Molecular Weight
1064.16
Storage Conditions
-20°C
Notes
For research use only.

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