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BCX-4430

CAT: 0013-GTR19155057-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155057-01Size:25 mg
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Description
A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.
CAS Number
222631-44-9
Purity
>98%
Smiles
Cl.OC[C@H]1N[C@@H] (C2=CNC3C (=NC=NC2=3) N) [C@H] (O) [C@@H]1O
Molecular Formula
C11H16ClN5O3
Molecular Weight
301.7294
Notes
For research use only.

Chemical Information

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-

Galidesivir Hydrochloride is the hydrochloride salt form of galidesivir, an adenosine analog and RNA polymerase inhibitor, with potential broad-spectrum antiviral activity. Upon administration, galidesivir is metabolized to its monophosphate form, which is then converted into the active triphosphate nucleotide. Galidesivir triphosphate binds to viral RNA-dependent RNA polymerase (RdRp) and gets incorporated into the growing viral RNA strand, which leads to premature chain termination. This prevents viral transcription and replication.

CAS Number222631-44-9
PubChem CID69211190
IUPAC Name(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride
Molecular FormulaC11H16ClN5O3
Molecular Weight301.73
Topological Polar Surface Area140
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity333
SMILES
C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O.Cl
InChI
InChI=1S/C11H15N5O3.ClH/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7;/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15);1H/t5-,7+,9-,10+;/m1./s1
InChIKey
PCCHVYNGFMEGIG-QPAIBFMUSA-N
Chemical Structure
2D Structure
2D structure of 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
CAS: 222631-44-9
CID: 69211190
Formula: C11H16ClN5O3
MW: 301.73
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight301.73
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass301.0941671
Monoisotopic Mass301.0941671
Topological Polar Surface Area140 Ų
Heavy Atom Count20
Formal Charge0
Complexity333
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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