Phosphoramide mustard (cyclohexanamine)

• Description:

  Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H302+H312+H332

• Target:

  DNA Alkylator/Crosslinker; Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/phosphoramide-mustard-cyclohexanamine.html

• Purity:

  98.0

• Solubility:

  H2O : ≥ 50 mg/mL

• Smiles:

  O=P(N(CCCl)CCCl)(N)O.NC1CCCCC1

• Molecular Formula:

  C10H24Cl2N3O2P

• Molecular Weight:

  320.20

• Precautions:

  H302+H312+H332

• References & Citations:

  [1]Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells. Toxicol Appl Pharmacol. 2015 Feb 1; 282 (3) : 252–258.|[2]S Genka, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol. 1990;27 (1) :1-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Climacteric. 2025 Jan 10:1-12.|Int J Nanomedicine. 2025 Aug 22:20:10195-10212.|J Funct Foods. 2025 Jun.|Sci Rep. 2024 Aug 16;14 (1) :19008.|Tufts University. 2025.|SSRN. 2024 Mar 21.|Stem Cell Res Ther. 2024 Apr 5;15 (1) :97.

• CAS Number:

  1566-15-0