Phosphoramide mustard (cyclohexanamine)

CAT: 0804-HY-137316A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137316A-01Size:5 mg
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Description
Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage[1][2].
CAS Number
[1566-15-0]
UNSPSC
12352211
Hazard Statement
H302+H312+H332
Target
DNA Alkylator/Crosslinker; Drug Metabolite
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phosphoramide-mustard-cyclohexanamine.html
Purity
98.0
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=P(N(CCCl)CCCl)(N)O.NC1CCCCC1
Molecular Formula
C10H24Cl2N3O2P
Molecular Weight
320.20
Precautions
H302+H312+H332
References & Citations
[1]Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells. Toxicol Appl Pharmacol. 2015 Feb 1; 282 (3) : 252–258.|[2]S Genka, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol. 1990;27 (1) :1-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Climacteric. 2025 Jan 10:1-12.|Int J Nanomedicine. 2025 Aug 22:20:10195-10212.|J Funct Foods. 2025 Jun.|Sci Rep. 2024 Aug 16;14 (1) :19008.|Tufts University. 2025.|SSRN. 2024 Mar 21.|Stem Cell Res Ther. 2024 Apr 5;15 (1) :97.

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